The CMA land data assimilation system (CLDAS) provides high spatio-temporal resolution datasets, which offers valuable data support for the fine meteorological services, while the applicability assessment of data is an important basis for its application. Based on CN05.1 gridded observation data from the National Meteorological Information Center and observation data at 119 national meteorological stations in Inner Mongolia, the applicability of 2 m mean temperature and precipitation products of CLDAS in Inner Mongolia was examined and evaluated, and was compared with ERA5 from the European Centre for Medium-range Weather Forecasts (ECMWF) and the CRU TS (Climatic Research Unit gridded Time Series) reanalysis data from the UK. The results indicate that three datasets can effectively reflect the spatial distribution characteristics of annual precipitation and annual mean temperature in Inner Mongolia, but they underestimate annual precipitation and overestimate annual mean temperature in most areas, and CLDAS datasets can also describe the influence of terrain change on temperature and precipitation. The spatial distributions of precipitation variability from CLDAS and CRU TS data are better than that from ERA5 data in Inner Mongolia. The linear trends of CRU TS and ERA5 temperature data are similar to CN05.1 observation data, but the warming rates are higher than observations, while the CLDAS temperature product shows the cooling trend in local areas of Inner Mongolia. Whether monthly or seasonal scale, the correlation coefficients between CLDAS precipitation, mean temperature and observation values at 119 stations in Inner Mongolia are higher than those of CRU TS and ERA5 data, and their average absolute errors are smaller than those of CRU TS and ERA5 data. Compared with the station observation data, the largest errors of CLDAS temperature and precipitation products appear in the Hetao region of Inner Mongolia.